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Article

Large case-control study indicates no association of KIR genotype and risk of developing acute myeloid leukemia.

Blood advances - 11 Jul 2023

Heidenreich Falk, Falk Bose, Baldauf Henning, Massalski Carolin, Schäfer Gesine, Rücker-Braun Elke, Altmann Heidi, Sauter Jürgen, Solloch Ute V, Lange Vinzenz, Stölzel Friedrich, Röllig Christoph, Middeke Jan M, von Bonin Malte, Thiede Christian, Schäfer-Eckart Kerstin, Müller-Tidow Carsten, Krause Stefan W, Kraus Sabrina, Kaufmann Martin, Hänel Mathias, Serve Hubert, Neubauer Andreas, Bornhäuser Martin, Schmidt Alexander H, Schetelig Johannes

Abstract excerpt

Immunogenetic association studies may give rise to new hypotheses on the immune surveillance of cancer. We hypothesized that certain combinations of killer immunoglobulin-like receptor (KIR) and HLA genotypes may enhance natural killer (NK) cell immunity against nascent acute myeloid leukemia (AML) and, thereby, lead to a skewed genotype distribution among patients. For this purpose, we analyzed KIR and HLA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36689727
DOI: 10.1182/bloodadvances.2022008514
PMCID: PMC10320196

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