Article
Utility of a buccal swab point-of-care test for the IFNL4 genotype in the era of direct acting antivirals for hepatitis C virus.
PloS one - 1 Jan 2023
Sy Aminata, McCabe Leanne, Hudson Emma, Ansari Azim M, Pedergnana Vincent, Lin Shang-Kuan, Santana S, Fiorino Marzia, Ala Aftab, Stone Ben, Smith M, Nelson Mark, Barclay Stephen T, McPherson Stuart, Ryder Stephen D, Collier Jane, Barnes Eleanor, Walker Ann Sarah, Pett Sarah L, Cooke Graham
Abstract excerpt
BACKGROUND: The CC genotype of the IFNL4 gene is known to be associated with increased Hepatitis C (HCV) cure rates with interferon-based therapy and may contribute to cure with direct acting antivirals. The Genedrive® IFNL4 is a CE marked Point of Care (PoC) molecular diagnostic test, designed for in vitro diagnostic use to provide rapid, real-time detection of IFNL4 genotype status for SNP rs12979860. METHODS:...
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