Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulated UPR and ER Stress Related to a Mutation in the Sdf2l1 Gene Are Involved in the Pathophysiology of Diet-Induced Diabetes in the Cohen Diabetic Rat.

International journal of molecular sciences - 10 Jan 2023

Yagil Chana, Varadi-Levi Ronen, Ifrach Chen, Yagil Yoram

Abstract excerpt

The Cohen Diabetic rat is a model of type 2 diabetes mellitus that consists of the susceptible (CDs/y) and resistant (CDr/y) strains. Diabetes develops in CDs/y provided diabetogenic diet (DD) but not when fed regular diet (RD) nor in CDr/y given either diet. We recently identified in CDs/y a deletion in Sdf2l1, a gene that has been attributed a role in the unfolded protein response (UPR) and in the prevention of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to Diet

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Stress

Share to Endoplasmic Reticulum Stress and Disease

Share to Insulin

Share to Mutation

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 36674879
DOI: 10.3390/ijms24021355
PMCID: PMC9866835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulated UPR and ER Stress Related to a Mutation in the Sdf2l1 Gene Are Involved in the Pathophysiology of Diet-Induced Diabetes in the Cohen Diabetic Rat.PMID 36674879Read ↗

The newly inbred cohen diabetic rat: a nonobese normolipidemic genetic model of diet-induced type 2 diabetes expressing sex differences.Semantic proximity Read ↗

A novel mutation in the NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (Ndufa4) gene links mitochondrial dysfunction to the development of diabetes in a rodent modelSemantic proximity Read ↗

Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.Semantic proximity Read ↗

Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence.Semantic proximity Read ↗

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetesSemantic proximity Read ↗

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetesSemantic proximity Read ↗

SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells.Semantic proximity Read ↗

Sex-specific genetic dissection of diabetes in a rodent model identifies Ica1 and Ndufa4 as major candidate genes.Semantic proximity Read ↗

Regulation of the Homeostatic Unfolded Protein Response in Diabetic NephropathySemantic proximity Read ↗

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes.Semantic proximity Read ↗

Monogenic and syndromic diabetes due to endoplasmic reticulum stressSemantic proximity Read ↗

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.