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Creation of Yeast Models for Evaluating the Pathogenicity of Mutations in the Human Mitochondrial Gene MT-ATP6 and Discovering Therapeutic Molecules.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Tribouillard-Tanvier Déborah, Dautant Alain, Godard François, Charles Camille, Panja Chiranjit, di Rago Jean-Paul, Kucharczyk Roza

Abstract excerpt

Numerous diseases in humans have been associated with mutations of the mitochondrial genome (mtDNA). This genome encodes 13 protein subunits of complexes involved in oxidative phosphorylation (OXPHOS), a process that provides aerobic eukaryotes with the energy-rich adenosine triphosphate molecule (ATP). Mutations of the mtDNA may therefore have dramatic consequences especially in tissues and organs with high...

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PMID: 35771445
DOI: 10.1007/978-1-0716-2309-1_14

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