Article

Simulated microgravity induces HIF-1-dependent pseudohypoxic and glycolytic state in triple- negative breast cancer

2025-12-16

Abstract excerpt

<title>Abstract</title> <p> With the expansion of commercial spaceflight and space exploration, the microgravity environment provides unparalleled opportunities to fight against challenging diseases. Here, we investigate the impact of simulated microgravity (sMG) on the cellular morphology and metabolic state of triple-negative breast cancer (TNBC). TNBC cells (SUM159 and MDA-MB-231) were exposed to sMG (~0.001...

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Literature Corpus work: 22096890-b287-57a5-8477-f43fc5c49537
DOI: 10.21203/rs.3.rs-7839613/v1

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