Article
The Effects of Drug Exposure and Single Nucleotide Polymorphisms on Aaptinib-Induced Severe Toxicities in Solid Tumors.
Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2023
Chen Youhao, Lin Yaobin, Guan Shaoxing, Zhao Zerui, Lin Daren, Guan Jin, Zhou Chengzhi, Liu Junling, Cao Xiaolong, Lin Zhichao, Chen Diyao, Shang Jianbiao, Zhang Weijian, Chen Huohui, Chen Likun, Ma Shudong, Gu Lijia, Zhao Jian, Huang Min, Wang Xueding, Long Hao
Abstract excerpt
To investigate the value of drug exposure and host germline genetic factors in predicting apatinib (APA)-related toxicities. METHOD: In this prospective study, plasma APA concentrations were quantified using liquid chromatography with tandem mass spectrometry, and 57 germline mutations were genotyped in 126 advanced solid tumor patients receiving 250 mg daily APA, a vascular endothelial growth factor receptor II...
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