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Article

Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss.

PLoS genetics - 1 Nov 2023

Lewis Morag A, Schulte Jennifer, Matthews Lois, Vaden Kenneth I, Steves Claire J, Williams Frances M K, Schulte Bradley A, Dubno Judy R, Steel Karen P

Abstract excerpt

Adult-onset progressive hearing loss is a common, complex disease with a strong genetic component. Although to date over 150 genes have been identified as contributing to human hearing loss, many more remain to be discovered, as does most of the underlying genetic diversity. Many different variants have been found to underlie adult-onset hearing loss, but they tend to be rare variants with a high impact upon the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38011198
DOI: 10.1371/journal.pgen.1011058
PMCID: PMC10718637

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