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Article

Efficient gene-environment interaction testing through bootstrap aggregating.

Scientific reports - 17 Jan 2023

Lau Michael, Kress Sara, Schikowski Tamara, Schwender Holger

Abstract excerpt

Gene-environment (GxE) interactions are an important and sophisticated component in the manifestation of complex phenotypes. Simple univariate tests lack statistical power due to the need for multiple testing adjustment and not incorporating potential interplay between several genetic loci. Approaches based on internally constructed genetic risk scores (GRS) require the partitioning of the available sample into...

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PMID: 36650248
DOI: 10.1038/s41598-023-28172-4
PMCID: PMC9845231

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