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Article

Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies.

BMC genetics - 16 Dec 2017

Hüls Anke, Krämer Ursula, Carlsten Christopher, Schikowski Tamara, Ickstadt Katja, Schwender Holger

Abstract excerpt

BACKGROUND: Weighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions. To assign weights, the gold standard is to use external weights from an independent study. However, appropriate external weights are not always available. In such situations and in the presence of...

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Identifiers

PMID: 29246113
DOI: 10.1186/s12863-017-0586-3
PMCID: PMC5732390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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