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Article

Re-trafficking of hERG reverses long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes.

Cardiovascular research - 1 Jun 2014

Mehta Ashish, Sequiera Glen Lester, Ramachandra Chrishan J A, Sudibyo Yuliansa, Chung Yingying, Sheng Jingwei, Wong Keng Yean, Tan Teng Hong, Wong Philip, Liew Reginald, Shim Winston

Abstract excerpt

AIMS: Long QT syndrome 2 (LQTS2) caused by missense mutations in hERG channel is clinically associated with abnormally prolonged ventricular repolarization and sudden cardiac deaths. Modelling monogenic arrhythmogenic diseases using human-induced pluripotent stem cells (hiPSCs) offers unprecedented mechanistic insights into disease pathogenesis. We utilized LQTS2-hiPSC-derived cardiomyocytes (CMs) to elucidate...

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Source

Identifiers

PMID: 24623279
DOI: 10.1093/cvr/cvu060

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Re-trafficking of hERG reverses long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes.PMID 24623279Read ↗

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