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Characterization of a Conjugative Hybrid Plasmid Coharboring bla KPC-2 and bla IMP-4 in a Klebsiella quasipneumoniae Clinical Isolate

10 Jan 2023

Abstract excerpt

strains. Our study described the cooccurrence of KPC-2, a serine β-lactamase, and IMP-4, a metallo-β-lactamase (MBL), on a conjugative hybrid plasmid from a clinical carbapenem-resistant K. quasipneumoniae strain, and it revealed an alternative route for IncHI5 plasmid to evolve by recombining with other plasmids to form a hybrid plasmid. Moreover, this hybrid plasmid can be transferred into other Klebsiella...

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PMID: 36625668
DOI: 10.1128/spectrum.02616-22

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