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Global dissemination of conjugative virulence plasmids co-harboring hypervirulence and multidrug resistance genes in Klebsiella pneumoniae

25 Mar 2025

Abstract excerpt

ABSTRACT Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hv Kp ) has led to a high mortality rate in the clinical setting and garnered significant attention in the clinical and scientific communities. It is still not clear which major mechanisms mediate the rapid evolution of hv Kp in clinical settings since the plasmid-encoding hypervirulence phenotype is considered non-conjugative. In this study,...

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PMID: 40130870
DOI: 10.1128/msystems.01675-24

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