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Social stress-induced serotonin dysfunction activates spexin in male Nile tilapia ( Oreochromis Niloticus )

9 Jan 2023

Abstract excerpt

Social disturbance in interpersonal relationships is the primary source of stress in humans. Spexin (SPX, SPX1a in cichlid), an evolutionarily conserved neuropeptide with diverse physiological functions, is up-regulated in the brain during chronic social defeat stress in teleost. On the other hand, repeated exposure to social stress can lead to dysregulation of the monoaminergic system and increase the...

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PMID: 36623187
DOI: 10.1073/pnas.2117547120

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