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SPOC domain-containing protein 1 regulates the proliferation and apoptosis of human spermatogonial stem cells through adenylate kinase 4

20 Dec 2022

Abstract excerpt

BACKGROUND: Spermatogonial stem cells (SSCs) are the origin of male spermatogenesis, which can reconstruct germ cell lineage in mice. However, the application of SSCs for male fertility restoration is hindered due to the unclear mechanisms of proliferation and self-renewal in humans. AIM: To investigate the role and mechanism of SPOC domain-containing protein 1 (SPOCD1) in human SSC proliferation. METHODS: We...

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PMID: 36619695
DOI: 10.4252/wjsc.v14.i12.822

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