Article
RGS14 binding to GNAI3 regulates human SSC proliferation and apoptosis through PLPP2, and abnormalities in these genes are associated with azoospermia
2025-01-08
Abstract excerpt
<title>Abstract</title> <p>Background Non-obstructive azoospermia (NOA) is a severe form of male infertility characterized by the absence of sperm in the ejaculate due to impaired spermatogenesis. Spermatogonial stem cells (SSCs) play a crucial role in maintaining male fertility by ensuring continuous sperm production. However, the molecular mechanisms regulating SSC fate and their involvement in NOA remain larg...
Topics
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- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ovarian function and disorders
- Pregnancy-related medical research
- Proteoglycans and glycosaminoglycans research
- Reproductive Biology and Fertility
- Reproductive biology and impacts on aquatic species
- Sperm and Testicular Function
- Testicular diseases and treatments
Identifiers and source
- Literature Corpus work
- 09bebf0c-2c55-5d6d-a4d5-d1933a0d3c2f
- DOI
- 10.21203/rs.3.rs-5770052/v1
