Article
Multiomics identification of programmed cell death-related characteristics for nonobstructive azoospermia based on a 675-combination machine learning computational framework.
Genomics - 1 Jan 2025
Huang Shuqiang, Tan Cuiyu, Chen Wanru, Zhang Tongtong, Xu Liying, Li Zhihong, Chen Miaoqi, Yuan Xiaojun, Chen Cairong, Yan Qiuxia
Abstract excerpt
BACKGROUND: Abnormal programmed cell death (PCD) plays a central role in spermatogenic dysfunction. However, the molecular mechanisms and biomarkers of PCD in patients with nonobstructive azoospermia (NOA) remain unclear. METHODS: The genetic conditions of NOA patients were analysed using bulk transcriptomic, single-cell transcriptomic, single nucleotide polymorphism (SNP), and clinical data from multiple...
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