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Article

Splice-Site Variants in the Gene Encoding GABA-A Receptor Delta Subunit Are Associated with Amphetamine Use in Patients under Methadone Maintenance Treatment.

International journal of molecular sciences - 31 Dec 2022

Lin Yen-Feng, Chou Wen-Hai, Liu Tung-Hsia, Fang Chiu-Ping, Kuo Hsiang-Wei, Kuo Po-Hsiu, Tsai Shih-Jen, Wang Sheng-Chang, Chung Ren-Hua, Tsou Hsiao-Hui, Chen Andrew C H, Liu Yu-Li

Abstract excerpt

Chronic opioid use disorder patients often also use other substances such as amphetamines. The gene-based analysis method was applied in the genomic database obtained from our previous study with 343 methadone maintenance treatment (MMT) patients. We found that the gene encoding gamma-aminobutyric acid type A receptors (GABA-A receptor) delta subunit isoforms (GABRD) was associated with amphetamine use in heroin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36614162
DOI: 10.3390/ijms24010721
PMCID: PMC9820820

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