Article
BRCAness predicts resistance to taxane-containing regimens in triple negative breast cancer during neoadjuvant chemotherapy.
Clinical breast cancer - 1 Feb 2015
Akashi-Tanaka Sadako, Watanabe Chie, Takamaru Tomoko, Kuwayama Takashi, Ikeda Murasaki, Ohyama Hiroto, Mori Miki, Yoshida Reiko, Hashimoto Rikako, Terumasa Sawada, Enokido Katsutoshi, Hirota Yuko, Okuyama Hiromi, Nakamura Seigo
Abstract excerpt
BACKGROUND: To provide optimal treatment of heterogeneous triple negative breast cancer (TNBC), we need biomarkers that can predict the chemotherapy response. PATIENTS AND METHODS: We retrospectively investigated BRCAness in 73 patients with breast cancer who had been treated with taxane- and/or anthracycline-based neoadjuvant chemotherapy (NAC). Using multiplex, ligation-dependent probe amplification on...
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