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Article

BRAFV600E Mutation Enhances Estrogen-Induced Metastatic Potential of Thyroid Cancer by Regulating the Expression of Estrogen Receptors.

Endocrinology and metabolism (Seoul, Korea) - 1 Dec 2022

Kim Minjun, Kim Su-Jin, Ha Seong Yun, Xu Zhen, Han Youngjin, Jee Hyeon-Gun, Cho Sun Wook, Park Young Joo, Lee Kyu Eun

Abstract excerpt

BACKGRUOUND: Cross-talk between mitogen-activated protein kinase and estrogen has been reported; however, the role of BRAFV600E in the estrogen responsiveness of thyroid cancer is unknown. We elucidated the effect of BRAFV600E on the estrogen-induced increase in metastatic potential in thyroid cancer. METHODS: Using a pair of cell lines, human thyroid cell lines which harbor wild type BRAF gene (Nthy/WT) and...

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Identifiers

PMID: 36604958
DOI: 10.3803/EnM.2022.1563
PMCID: PMC9816508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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