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Article

Metastatic phenotype is regulated by estrogen in thyroid cells.

Thyroid : official journal of the American Thyroid Association - 1 Jan 2010

Rajoria Shilpi, Suriano Robert, Shanmugam Arulkumaran, Wilson Yushan Lisa, Schantz Stimson P, Geliebter Jan, Tiwari Raj K

Abstract excerpt

BACKGROUND: Over 200 million people worldwide are affected by thyroid proliferative diseases, including cancer, adenoma, and goiter, annually. The incidences of thyroid malignancies are three to four times higher in women, suggesting the possible involvement of estrogen. Based on this observed sex bias, we hypothesize that estrogen modulates the growth and metastatic propensity of thyroid cancer cells. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20067378
DOI: 10.1089/thy.2009.0296
PMCID: PMC2833180

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