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Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus

4 Jan 2023

Abstract excerpt

Abstract Broad-spectrum β-lactam antibiotic resistance in Staphylococcus aureus is a global healthcare burden 1,2 . In clinical strains, resistance is largely controlled by BlaR1 3 , a receptor that senses β-lactams through the acylation of its sensor domain, inducing transmembrane signalling and activation of the cytoplasmic-facing metalloprotease domain 4 . The metalloprotease domain has a role in BlaI...

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Share to Antibiotic Resistance in Bacteria
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PMID: 36599987
DOI: 10.1038/s41586-022-05583-3

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