Article
Construction of molecular subgroups in childhood systemic lupus erythematosus using bioinformatics.
Medicine - 23 Dec 2022
Ma Jianglei, Zhang Huijie, Chu Weijiang, Wang Pengyu, Chen Huaqiu, Zhang Yuanyuan, Wang Guangming
Abstract excerpt
BACKGROUND: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder. In patients with childhood SLE (cSLE), the onset of the disease occurs before 18 years of age and accounts for a high proportion of childhood autoimmune diseases. Adult SLE and cSLE differ in terms of clinical manifestations, gene expression profiles, and treatment. Because current diagnostic methods do not meet clinical...
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