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Common targetable inflammatory pathways in brain transcriptome of autism spectrum disorders and Tourette syndrome

15 Dec 2022

Abstract excerpt

Neurodevelopmental disorders (NDDs), including autism-spectrum disorders (ASD) and Tourette syndrome (TS) are common brain conditions which often co-exist, and have no approved treatments targeting disease mechanisms. Accumulating literature implicates the immune system in NDDs, and transcriptomics of post-mortem brain tissue has revealed an inflammatory signal. We interrogated two RNA-sequencing datasets of ASD...

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PMID: 36590292
DOI: 10.3389/fnins.2022.999346

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