Article
ETNK1 mutation occurs in a wide spectrum of myeloid neoplasms and is not specific for atypical chronic myeloid leukemia.
Cancer - 15 Mar 2023
Shuai Wen, Zuo Zhuang, Li Nianyi, Garces Sofia, Jelloul Fatima Zahra, Ok Chi Young, Li Shaoying, Xu Jie, You M James, Wang Wei, Rehder Catherine, Jabbour Elias J, Patel Keyur P, Medeiros L Jeffrey, Yin C Cameron
Abstract excerpt
BACKGROUND: ETNK1 mutation has been suggested as a useful tool to support the diagnosis of atypical chronic myeloid leukemia. ETNK1 mutations, however, occur in other myeloid neoplasms. METHODS: The authors assessed the clinicopathologic and molecular genetic features of 80 ETNK1-mutated myeloid neoplasms. RESULTS: Thirty-seven neoplasms (46%) were classified as myelodysplastic syndrome, 17 (21%) were classified...
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