Article
Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease.
Molecular psychiatry - 1 Mar 2023
Varma Vijay R, Desai Rishi J, Navakkode Sheeja, Wong Lik-Wei, Anerillas Carlos, Loeffler Tina, Schilcher Irene, Mahesri Mufaddal, Chin Kristyn, Horton Daniel B, Kim Seoyoung C, Gerhard Tobias, Segal Jodi B, Schneeweiss Sebastian, Gorospe Myriam, Sajikumar Sreedharan, Thambisetty Madhav
Abstract excerpt
We recently nominated cytokine signaling through the Janus-kinase-signal transducer and activator of transcription (JAK/STAT) pathway as a potential AD drug target. As hydroxychloroquine (HCQ) has recently been shown to inactivate STAT3, we hypothesized that it may impact AD pathogenesis and risk. Among 109,124 rheumatoid arthritis patients from routine clinical care, HCQ initiation was associated with a lower...
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