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Article

Immunosuppressant Use Mediates Neuroprotection Against Alzheimer's Disease in Rheumatoid Arthritis-A Two-Step Mendelian Randomization and NHANES Study.

International journal of rheumatic diseases - 1 Aug 2026

Chen Cong, Cheng Jian, Yang Min, Li Ji-Ping, Tao Sha-Sha, Wang Peng, Pan Hai-Feng

Abstract excerpt

OBJECTIVES: To investigate whether immunosuppressant (IS) use contributes to the inverse association between rheumatoid arthritis (RA) and Alzheimer's disease (AD). METHODS: We analyzed NHANES 2011-2014 data, including 217 RA patients aged ≥ 60 years on prescription medications. Cognitive function was assessed using the Digit Symbol Substitution Test (DSST), CERAD, Animal Fluency Test (AFT), and a global...

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Identifiers

PMID: 42581442
DOI: 10.1111/1756-185x.70823
PMCID: PMC13462337

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