Article
Trojan Horse Nanocapsule Enabled In Situ Modulation of the Phenotypic Conversion of Th17 Cells to Treg Cells for the Treatment of Multiple Sclerosis in Mice.
Advanced materials (Deerfield Beach, Fla.) - 1 Mar 2023
Shi Chongdeng, Zhang Jing, Wang Huijun, Chen Chen, Han Maosen, Gao Lin, Tang Chunwei, Sun Peng, Zhao Xiaotian, Guo Feiyue, Wang Zhaozhong, Abdalla Mohnad, Yang Zhenmei, Liu Ying, Li Anning, Zhang Cai, Jiang Xinyi
Abstract excerpt
Th17/Treg imbalance is closely related to the occurrence and development of multiple sclerosis (MS), and the transdifferentiation of Th17 cells into Treg cells may contribute to the resolution of inflammation, presenting a therapeutic strategy for MS. To modulate this phenotypic shift in situ, a "Trojan horse"-like hybrid system, nanocapsule-coupled Th17 cells, is reported for MS treatment. Following intravenous...
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