Article
Novel genes controlling ventral cord asymmetry and navigation of pioneer axons in C. elegans.
Developmental biology - 1 Aug 2005
Hutter Harald, Wacker Irene, Schmid Christina, Hedgecock Edward M
Abstract excerpt
The ventral cord in C. elegans is the major longitudinal axon tract containing essential components of the motor circuit. In genetic screens using transgenic animals expressing neuron specific GFP reporters, we identified twelve genes required for the correct outgrowth of interneuron axons of the motor circuit. In mutant animals, axons fail to navigate correctly towards the ventral cord or fail to fasciculate...
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