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The Role of Tumor Microenvironment in Regulating the Plasticity of Osteosarcoma Cells

18 Dec 2022

Abstract excerpt

Osteosarcoma (OS) is a malignancy that is becoming increasingly common in adolescents. OS stem cells (OSCs) form a dynamic subset of OS cells that are responsible for malignant progression and chemoradiotherapy resistance. The unique properties of OSCs, including self-renewal, multilineage differentiation and metastatic potential, 149 depend closely on their tumor microenvironment. In recent years, the likelihood...

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PMID: 36555795
DOI: 10.3390/ijms232416155

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