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Article

Evidence for the osteosarcoma stem cell

18 Jun 2011

Abstract excerpt

Osteosarcoma is a highly malignant bone tumor of children and young adults. Cytotoxic chemotherapy combined with aggressive surgery only has a 60% survival rate. Historically, chemotherapy has been developed assuming that all cells within a particular cancer are clonal and near identical. Appreciating the now apparent functional heterogeneity of osteosarcoma cells within and between individual tumors will likely...

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PMID: 21755019
DOI: 10.1097/bco.0b013e318221aee8

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