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Article

Evolution and molecular basis of a novel allosteric property of crocodilian hemoglobin.

Current biology : CB - 9 Jan 2023

Natarajan Chandrasekhar, Signore Anthony V, Bautista Naim M, Hoffmann Federico G, Tame Jeremy R H, Fago Angela, Storz Jay F

Abstract excerpt

The extraordinary breath-hold diving capacity of crocodilians has been ascribed to a unique mode of allosterically regulating hemoglobin (Hb)-oxygenation in circulating red blood cells. We investigated the origin and mechanistic basis of this novel biochemical phenomenon by performing directed mutagenesis experiments on resurrected ancestral Hbs. Comparisons of Hb function between the common ancestor of...

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Identifiers

PMID: 36549299
DOI: 10.1016/j.cub.2022.11.049
PMCID: PMC9839640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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