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Altered gut microbiome composition by appendectomy contributes to colorectal cancer

20 Dec 2022

Abstract excerpt

Appendectomy impacts the homeostasis of gut microbiome in patients. We aimed to study the role of appendectomy in colorectal cancer (CRC) risk through causing gut microbial dysbiosis. Population-based longitudinal study (cohort 1, n = 129,155) showed a 73.0% increase in CRC risk among appendectomy cases throughout 20 years follow-up (Adjusted sub-distribution hazard ratio (SHR) 1.73, 95% CI 1.49-2.01, P < 0.001)....

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PMID: 36539569
DOI: 10.1038/s41388-022-02569-3

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