Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells.

doi:10.1158/1078-0432.CCR-22-2538

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Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2023

van 't Erve Iris, Medina Jamie E, Leal Alessandro, Papp Eniko, Phallen Jillian, Adleff Vilmos, Chiao Elaine Jiayuee, Arun Adith S, Bolhuis Karen, Simmons John K, Karandikar Aanavi, Valkenburg Kenneth C, Sausen Mark, Angiuoli Samuel V, Scharpf Robert B, Punt Cornelis J A, Meijer Gerrit A, Velculescu Victor E, Fijneman Remond J A

Abstract excerpt

PURPOSE: Circulating tumor DNA (ctDNA) has the potential to guide therapy selection and monitor treatment response in patients with metastatic cancer. However, germline and clonal hematopoiesis-associated alterations can confound identification of tumor-specific mutations in cell-free DNA (cfDNA), often requiring additional sequencing of tumor tissue. The current study assessed whether ctDNA-based treatment...

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PMID: 36534496
DOI: 10.1158/1078-0432.CCR-22-2538
PMCID: PMC9975664

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