Giant cell arteritis--a molecular approach to the multiple facets of the syndrome.

Article

Giant cell arteritis--a molecular approach to the multiple facets of the syndrome.

Annales de medecine interne - 1 Nov 1998

Weyand C M, Hafner V, Kaiser M, Goronzy J J

Abstract excerpt

Molecular studies of giant cell arteritis indicate that T cells are recruited to the wall of medium-sized and large arteries, are activated locally, produce IL-2 and IFN-gamma, and regulate the activity of tissue-infiltrating macrophages. Downstream effects of T cell activation include the produc...

Topics

Brain Ischemia
Cytokines
Giant Cell Arteritis
Growth Substances
Humans
Lymphocyte Activation
Macrophages
Molecular Biology
Phenotype
Polymyalgia Rheumatica
T-Lymphocytes

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