Article
Giant cell arteritis--a molecular approach to the multiple facets of the syndrome.
Annales de medecine interne - 1 Nov 1998
Weyand C M, Hafner V, Kaiser M, Goronzy J J
Abstract excerpt
Molecular studies of giant cell arteritis indicate that T cells are recruited to the wall of medium-sized and large arteries, are activated locally, produce IL-2 and IFN-gamma, and regulate the activity of tissue-infiltrating macrophages. Downstream effects of T cell activation include the production of proinflammatory cytokines, metalloproteinases, and growth factors. Growth factors are instrumental in the...
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