Article
Site-Directed Mutation of Salicylate Decarboxylase Gene and Mechanism of Ginkgo Acid Decarboxylation.
The protein journal - 1 Feb 2023
Song Yuanyuan, Hu Yanying, Li Jiaxin, Wang Lin, Jing Wenjie, Zhang Liming, Dai Yujie, Jia Shiru, Meng Xuan, Zhang Huitu
Abstract excerpt
Ginkgo seed is an important Chinese medicine and food resource in China, but the toxicity of ginkgo acid in it limits its application. Previous studies have found that salicylic acid decarboxylase (Sdc) has a decarboxylation degradation effect on ginkgo acid. In order to improve the decarboxylation ability of Sdc to Ginkgo acid, 11 residues of the Sdc around the substrate (salicylic acid) were determined as...
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