Article
Application of mixed linear models for the estimation of functional effects on bovine stature based on SNP summary statistics from a whole-genome association study.
Genetics, selection, evolution : GSE - 16 Dec 2022
Kotlarz Krzysztof, Kosinska-Selbi Barbara, Cai Zexi, Sahana Goutam, Szyda Joanna
Abstract excerpt
Genome-wide association studies (GWAS) help identify polymorphic sites or genes linked to phenotypic variance, but a few identified genes and/or single nucleotide polymorphisms (SNPs) are unlikely to explain a large part of the phenotypic variability of complex traits. In this study, the focus was moved from single loci to functional units, expressed by the metabolic pathways as defined in the Kyoto Encyclopaedia...
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