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Single‐cell transcriptomic analysis of the role of HPV16‐positive macrophages in cervical cancer prognosis

15 Dec 2022

Abstract excerpt

Abstract Almost all cases of cervical cancer (CC) can be attributed to high‐risk human papillomavirus (HPVs) infections in keratinocytes. However, it is unknown whether HPV invades immune cells such as macrophages and T cells. We analyzed the single‐cell transcriptome of the CC and its adjacent tissues and found that HPV16 genes, including E1, E6, and E7, expressed in the macrophages and CD8 + T cells in addition...

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PMID: 36519591
DOI: 10.1002/jmv.28410

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