Article
Prevalence of sexual dimorphism in mammalian phenotypic traits.
Nature communications - 26 Jun 2017
Karp Natasha A, Mason Jeremy, Beaudet Arthur L, Benjamini Yoav, Bower Lynette, Braun Robert E, Brown Steve D M, Chesler Elissa J, Dickinson Mary E, Flenniken Ann M, Fuchs Helmut, Angelis Martin Hrabe de, Gao Xiang, Guo Shiying, Greenaway Simon, Heller Ruth, Herault Yann, Justice Monica J, Kurbatova Natalja, Lelliott Christopher J, Lloyd K C Kent, Mallon Ann-Marie, Mank Judith E, Masuya Hiroshi, McKerlie Colin, Meehan Terrence F, Mott Richard F, Murray Stephen A, Parkinson Helen, Ramirez-Solis Ramiro, Santos Luis, Seavitt John R, Smedley Damian, Sorg Tania, Speak Anneliese O, Steel Karen P, Svenson Karen L, Wakana Shigeharu, West David, Wells Sara, Westerberg Henrik, Yaacoby Shay, White Jacqueline K
Abstract excerpt
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has...
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