Tachyplesin I and its derivatives: A pharmaco-chemical perspective on their antimicrobial and antitumor potential

Abstract excerpt

INTRODUCTION: Increasing evidence suggests that intratumor microbiota are an intrinsic component in the tumor microenvironment across multiple cancer types, and that there is a close relationship between microbiota and tumor progression. Therefore, how to address the interaction between bacteria and malignances has become a growing concern. Tachyplesin I (TPI), a peptide with dual antimicrobial and antitumor...

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