Article
19S Proteasome Subunits as Oncogenes and Prognostic Biomarkers in FLT3-Mutated Acute Myeloid Leukemia (AML).
International journal of molecular sciences - 23 Nov 2022
Lara Joshua J, Bencomo-Alvarez Alfonso E, Gonzalez Mayra A, Olivas Idaly M, Young James E, Lopez Jose L, Velazquez Vanessa V, Glovier Steven, Keivan Mehrshad, Rubio Andres J, Dang Sara K, Solecki Jonathan P, Allen Jesse C, Tapia Desiree N, Tychhon Boranai, Astudillo Gonzalo E, Jordan Connor, Chandrashekar Darshan S, Eiring Anna M
Abstract excerpt
26S proteasome non-ATPase subunits 1 (PSMD1) and 3 (PSMD3) were recently identified as prognostic biomarkers and potential therapeutic targets in chronic myeloid leukemia (CML) and multiple solid tumors. In the present study, we analyzed the expression of 19S proteasome subunits in acute myeloid leukemia (AML) patients with mutations in the FMS-like tyrosine kinase 3 (FLT3) gene and assessed their impact on...
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