Article

An iTSC-derived placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility in syncytiotrophoblasts

2021-10-29

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19) has caused a global health crisis. The primary site of infection is in the respiratory tract but the virus has been associated with a variety of complications involving the gastrointestinal and cardiovascular systems. Since the virus affects a variety of tissue types, there has been interest in unders...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67613ff2-9f12-54fe-8882-3cbe9dc03acd
DOI: 10.1101/2021.10.27.465224

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An iTSC-derived placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility in syncytiotrophoblastsDOI 10.1101/2021.10.27.465224Read

A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblastsSemantic proximity Read

Human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infectionSemantic proximity Read

Is SARS-CoV-2 Infection a Risk Factor for Early Pregnancy Loss? ACE2 and TMPRSS2 Coexpression and Persistent Replicative Infection in Primitive TrophoblastSemantic proximity Read

<strong>Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors to Drive Pathogenesis of SARS-CoV-2 </strong>Semantic proximity Read

Human Early Syncytiotrophoblasts Are Highly Susceptible to SARS-CoV-2 InfectionSemantic proximity Read

Single‐cell RNA expression profiling of SARS‐CoV‐2‐related ACE2 and TMPRSS2 in human trophectoderm and placentaSemantic proximity Read

Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literatureSemantic proximity Read

Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2Semantic proximity Read

SARS-CoV-2 Transplacental Transmission: A Rare Occurrence? An Overview of the Protective Role of the PlacentaSemantic proximity Read

SARS-CoV-2 can infect and propagate in human placenta explantsSemantic proximity Read

Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimesterSemantic proximity Read

SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal–Fetal InterfaceSemantic proximity Read