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Prime Editing for the Installation and Correction of Mutations Causing Inherited Retinal Disease: A Brief Methodology.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Tsai Yi-Ting, da Costa Bruna Lopes, Nolan Nicholas D, Caruso Salvatore Marco, Jenny Laura A, Levi Sarah R, Tsang Stephen H, Quinn Peter M J

Abstract excerpt

Inherited retinal diseases (IRDs) encompass a large heterogeneous group of rare blinding disorders whose etiology originates from mutations in the 280 genes identified to date. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems represent a promising avenue for the treatment of IRDs, as exemplified by FDA clinical trial approval of EDIT-101 (AGN-151587), which...

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PMID: 36481907
DOI: 10.1007/978-1-0716-2651-1_29

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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