Article
CircRNA circCOL1A1 Acts as a Sponge of miR-30a-5p to Promote Vascular Smooth Cell Phenotype Switch through Regulation of Smad1 Expression.
Thrombosis and haemostasis - 1 Jan 2023
Ye Meng, Ni Qihong, Wang Han, Wang Yuli, Yao Yongjie, Li Yinan, Wang Weilun, Yang Shuofei, Chen Jiaquan, Lv Lei, Zhao Yiping, Xue Guanhua, Guo Xiangjiang, Zhang Lan
Abstract excerpt
Phenotypic switch of vascular smooth muscle cells (VSMCs) plays an important role in the pathogenesis of atherosclerosis. The mRNA expression of the synthetic biomarker Collagen Type I Alpha 1 Chain (COL1A1) gene is upregulated during the switch of VSMCs from the contractile to the synthetic phenotype. The association of noncoding circular RNAs transcribed by the COL1A1 gene with VSMC phenotype alteration and...
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