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Using unique molecular identifiers to improve allele calling in low-template mixtures.

Forensic science international. Genetics - 1 Mar 2023

Crysup Benjamin, Mandape Sammed, King Jonathan L, Muenzler Melissa, Kapema Kapema Bupe, Woerner August E

Abstract excerpt

PCR artifacts are an ever-present challenge in sequencing applications. These artifacts can seriously limit the analysis and interpretation of low-template samples and mixtures, especially with respect to a minor contributor. In medicine, molecular barcoding techniques have been employed to decrease the impact of PCR error and to allow the examination of low-abundance somatic variation. In principle, it should be...

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PMID: 36462297
DOI: 10.1016/j.fsigen.2022.102807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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