Article
Unknown biological mixtures evaluation using STR analytical quantification.
Electrophoresis - 1 Feb 2006
Shrestha Sadeep, Strathdee Steffanie A, Broman Karl W, Smith Michael W
Abstract excerpt
Allelic quantification of STRs, where the presence of three or more alleles represents mixtures, provides a novel method to identify mixtures from unknown biological sources. The allelic stutters resulting in slightly different repeat containing products during fragment amplification can be mistaken for true alleles complicating a simple approach to mixture analysis. An algorithm based on the array of estimated...
Topics
- Algorithms
- Alleles
- Cell Line
- Complex Mixtures
- Forensic Medicine
- Humans
- Oligonucleotides
- Polymerase Chain Reaction
- Tandem Repeat Sequences