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Article

ISG15 Is a Novel Regulator of Lipid Metabolism during Vaccinia Virus Infection

1 Dec 2022

Abstract excerpt

The functions of ISG15 are continuously expanding, and growing evidence supports its role as a relevant modulator of cell metabolism. In this work, we highlight how the absence of ISG15 impacts macrophage lipid metabolism in the context of viral infections and how poxviruses modulate metabolism to ensure successful replication. Our results open the door to new advances in the comprehension of macrophage...

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PMID: 36453897
DOI: 10.1128/spectrum.03893-22

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