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Glioma stem cells activate platelets by plasma-independent thrombin production to promote glioblastoma tumorigenesis

1 Jan 2022

Abstract excerpt

Abstract Background The interaction between platelets and cancer cells has been underexplored in solid tumor models that do not metastasize, for example, glioblastoma (GBM) where metastasis is rare. Histologically, it is known that glioma stem cells (GSCs) are found in perivascular and pseudsopalisading regions of GBM, which are also areas of platelet localization. High platelet counts have been associated with...

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PMID: 36452274
DOI: 10.1093/noajnl/vdac172

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