Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer.

Science translational medicine - 30 Nov 2022

Matsushima Shingo, Ajiro Masahiko, Iida Kei, Chamoto Kenji, Honjo Tasuku, Hagiwara Masatoshi

Abstract excerpt

Neoantigen production is a determinant of cancer immunotherapy. However, the expansion of neoantigen abundance for cancer therapeutics is technically challenging. Here, we report that the synthetic compound RECTAS can induce the production of splice-neoantigens that could be used to boost antitumor immune responses. RECTAS suppressed tumor growth in a CD8+ T cell- and tumor major histocompatibility complex class...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Immunotherapy

Share to Mutation

Source

Identifiers

PMID: 36449604
DOI: 10.1126/scitranslmed.abn6056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer.PMID 36449604Read ↗

Neoantigens: The Novel Precision Cancer ImmunotherapySemantic proximity Read ↗

Boosting Antitumor Immunity with an Expanded Neoepitope Landscape.Semantic proximity Read ↗

Personalized Neoantigen Vaccine plus Regorafenib Increases Rgs2⁺CD8⁺ T Cells Infiltration and Reprograms the Tumor Microenvironment in Microsatellite Stable Colorectal Cancer Liver MetastasesSemantic proximity Read ↗

Immunogenicity of Neoantigens in Colorectal Cancer: Potential Influence of Tumor Mutation Burden, Stages, and MetastasisSemantic proximity Read ↗

Cancer Neoantigen Vaccines Emerge Efficacious.Semantic proximity Read ↗

mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancerSemantic proximity Read ↗

Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4.Semantic proximity Read ↗

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigensSemantic proximity Read ↗

Identification of neoantigens for individualized therapeutic cancer vaccinesSemantic proximity Read ↗

Neoantigen polypeptide vaccines induce effective antitumor response in colorectal cancerSemantic proximity Read ↗

The neoantigens derived from transposable elements - A hidden treasure for cancer immunotherapy.Semantic proximity Read ↗

Identification of neoantigens in esophageal adenocarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.