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Article

Epigenetic profiling of biphenotypic sinonasal sarcoma across fusion variants and high-grade transformation.

Human pathology - 1 Jun 2026

Gomes Yuri Merlotti, de Castro João Víctor Alves, Gomes Nicolai Merlotti, Abreu Rodrigo Fonseca, Kulikowski Leslie Domenici, Wolff Beatriz Martins, Pinto Clóvis Antonio, Nascimento Antonio G, Toledo Ronaldo Nunes, Meyer Anders, Fernandes Igor Lima, Neto Cristovam Scapulatempo, Jurmeister Philipp, Capper David, Dermawan Josephine K, Fritchie Karen J, Bezerra Stephania Martins, Costa Felipe D'Almeida

Abstract excerpt

Biphenotypic sinonasal sarcoma (BSS) is a rare mesenchymal neoplasm characterized by dual neural and myogenic differentiation, recurrent PAX3 gene rearrangements, and low-grade morphology. High-grade transformation has been described, posing significant diagnostic challenges due to overlap among sinonasal tumors. DNA methylation profiling has emerged as a powerful diagnostic tool for sinonasal neoplasms, although...

Topics

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Cell Transformation, Neoplastic
DNA Methylation
Epigenesis, Genetic
Oncogene Proteins, Fusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Paranasal Sinus Neoplasms

PAX3 Transcription Factor

Trans-Activators

Source

Identifiers

PMID: 41720166
DOI: 10.1016/j.humpath.2026.106076

Genes

PAX3
FOXO1
FUS
MAML3
NCOA2
POU2AF3
YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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