Article
A Systems Analysis of Phenotype Heterogeneity in APOE*3Leiden.CETP Mice Induced by Long-Term High-Fat High-Cholesterol Diet Feeding.
Nutrients - 21 Nov 2022
Paalvast Yared, Zhou Enchen, Rozendaal Yvonne J W, Wang Yanan, Gerding Albert, van Dijk Theo H, de Boer Jan Freark, Rensen Patrick C N, van Dijk Ko Willems, Kuivenhoven Jan A, Bakker Barbara M, van Riel Natal A W, Groen Albert K
Abstract excerpt
Within the human population, considerable variability exists between individuals in their susceptibility to develop obesity and dyslipidemia. In humans, this is thought to be caused by both genetic and environmental variation. APOE*3-Leiden.CETP mice, as part of an inbred mouse model in which mice develop the metabolic syndrome upon being fed a high-fat high-cholesterol diet, show large inter-individual variation...
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